These mice also show diminished leptin-regulated feeding suppression, suggesting a direct impact of leptin on astrocyte development and function in adult mice (Kim et al., 2014) which is supported by studies demonstrating leptin-mediated neurogenesis post-stroke (Avraham et al., 2013) as well as a model of Alzheimer’s disease (Calio et al., 2021) in rodents. Here, LEP is linked to early-onset autosomal dominant Alzheimer disease.