Interestingly, more than a dozen RyR2 mutations originally identified in CPVT patients have been shown to increase Ca2+ leak (Jiang et al., 2002; Wehrens et al., 2003; Lehnart et al., 2004; Kontula et al., 2005; Tester et al., 2007; Lehnart et al., 2008; Marjamaa et al., 2011; Shan et al., 2012). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.