RYR2 and atrial fibrillation: For instance, RyR2 is oxidized in atrial tissue in vivo in a genetic model of catecholaminergic polymorphic ventricular tachycardia (CPVT), RyR2-R2474S+/− knockin mice, with increased susceptibility for pacing-induced atrial fibrillation (Shan et al., 2012).