CuE (0.25 and 0.5 mg/kg) post-treatment for 28 successive days considerably attenuated (p < .001, p < .001) the LDH activity [F(5,41) = 39.55, p < .001] (Figure 5A) and caspase-3 content [F(5,41) = 46.58, p < .001] (Figure 5B) in rats subjected to CH with respect to rats that were exposed to CH and vehicle treatments. Here, CASP3 is linked to cyclic hematopoiesis.