In Codonopsis Radix, luteolin might suppress cancer cell growth through hydrogen-bonding with AKT1, APP, CASP3, CCNA2, CCNB1, CDK1, CDK2, CDK5, FOS, JUN; glycitein could hydrogen-bond with CDK4, JUN, MAPK1, MAPK3; while stigmasterol only bound with TNF by van der Waals forces. This evidence concerns the gene MAPK3 and cancer.