To further explore the mechanisms of Qi-invigorating herbs acting on DLBCL TME, we conducted the analysis of the relationship between hub genes and tumor-infiltrating immune cells (B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, myeloid DCs, MDSCs) from the TIMER 2.0 database. This evidence concerns the gene CD4 and diffuse large B-cell lymphoma.