In DLBCL microenvironment, although much is still unknown concerning the composition of immune cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, myeloid DCs and MDSCs have been widely tested as independent predictors of DLBCL outcome (Azzaoui et al., 2016; Chen et al., 2016; Judd et al., 2017; Kusano et al., 2017; Ciavarella et al., 2018; Staiger et al., 2020; Merdan et al., 2021; Xu et al., 2021). The gene discussed is CD4; the disease is diffuse large B-cell lymphoma.