SOD1 and amyotrophic lateral sclerosis: Despite mutations in SOD1 gene are present in 20% of familiar ALS cases and only 2% of all ALS cases (Ragagnin et al., 2019), the interest of the SOD1 transgenic models is increased because alterations in SOD1 protein also occur in sporadic ALS cases (Bosco and Landers, 2010), and accumulation of wild-type SOD1 causes ALS (Graffmo et al., 2013).