In this work we show that inhibition of GSK3β with 9-ING-41 in KRAS mutant colorectal organoids leads to similar changes in the transcriptomic profile to the ones observed in KRAS mutant AML cells after suppression of STK33. Both these interventions were effective in prevention of the growth of malignant cells harboring KRAS mutations. Here, GSK3B is linked to acute myeloid leukemia.