SIRT1 and neoplasm: For example, the expression level of the antiaging gene Sirtuin 1 (Bosch-Presegué and Vaquero, 2014; Lee et al., 2019) was significantly associated with the depth of tumor invasion, differentiation, and tumor size in colorectal carcinoma (Yu et al., 2016; Sun et al., 2017; Simons et al., 2018).