ABCC2 and acute lymphoblastic leukemia: Lopez-Lopez et al. found SNPs rs2073337, rs4148396, and rs11192298 in the ABCC2 gene have no significant association with the development of neurotoxicity, but ABCC2 genotypes GG (rs3740066) and GG (rs12826) were associated with increased Grade I-IV VIPN in childhood ALL patients (Lopez-Lopez et al., 2016).