Previous studies have shown that Cav-1 located on caveolae of glomerular ECs (HRGECs) mediates albumin entry into glomerular ECs and transcytosis, leading to proteinuria in glomerular diseases, whereas MβCD can reverse the abovementioned changes (Moriyama et al., 2015; Moriyama et al., 2017). The gene discussed is CAV1; the disease is glomerular disorder.