MβCD and filipin can destroy the structure of caveolae and reduce Cav-1 phosphorylation and downstream signaling pathways, such as the Cav-1/RhoA and Scr/Cav-1/EGFR/Akt signaling pathways, resulting in the prevention of fibronectin and collagen I production and alleviation of glomerulosclerosis (Peng et al., 2007; Zhang et al., 2007). Here, CAV1 is linked to glomerulosclerosis.