HMGA1 and neoplasm: Further investigations have shown that the abnormally increased expression of Cav-1 in tumor cells is related to the methylation of CpG sites, and the upregulation of Cav-1 expression then increases the activity of HMGA1 and promotes the translocation of HMGA1 into the nucleus, where HMGA1 binds to the promoter of GLUT3 and promotes its transcription (Ha et al., 2012).