Recent animal and clinical studies strongly support that Nav1.7 plays an important role in the pathophysiology of dental disease, such as burning mouth syndrome (Beneng et al., 2010), inflamed TMJ (Bi et al., 2017), trigeminal neuralgia (Zakrzewska et al., 2017), and pulpitis (Aubeux et al., 2021). The gene discussed is SCN9A; the disease is trigeminal neuralgia.