It further activates caspase-1, releases mature forms of Interleukin-1β (IL-1β) and Interleukin-18 (IL-18), causes inflammatory response in the body, and participates in the occurrence and development of many diseases, including type 2 diabetes, gout, atherosclerosis, neurodegenerative diseases, tumor, and inflammatory bowel disease. The gene discussed is IL18; the disease is neurodegenerative disease.