CSF1R and osteopetrosis: Systemic Csf1r-knockout mice can exhibit osteopetrosis, reduction in marrow hematopoiesis, and defection in reproductive function, impairment in olfactory capacity, and reduction in mononuclear phagocyte, including microglia (Dai et al., 2002; Li et al., 2006; Chitu et al., 2016).