KCNT1 and Epileptic encephalopathy: Moreover, encephalopathies can also designate chronic brain states such as epileptic encephalopathies (for review, see Palmer et al., 2021) often sharing a genetic cause and encompassing a broad spectrum of developmental electroclinical syndromes characterized by subtle seizures and intellectual disabilities (like those caused by epileptic encephalopathies associated with KCNT1 mutations) (Ohba et al., 2015; Hansen et al., 2017).