APOE and metabolic dysfunction-associated steatotic liver disease: Interestingly, both NAFLD and dementia share two important biological risk factors, such as Apolipoprotein E (APO-E) (Yang et al., 2005; Rasmussen, 2016) and Adiponectin (ADPN) (Buechler et al., 2011; Rizzo et al., 2020).