We demonstrated an early impairment of non-cognitive AD-like symptoms, i.e., deficits in social interest, interaction, and communication in 4∼5 month-old APP/PS1 mice (Figure 8), similar to previous findings of deficits in social memory in 3∼6 month-old APP/PS1 mice (Filali et al., 2011; Pietropaolo et al., 2012). This evidence concerns the gene PSEN1 and Alzheimer disease.