PSEN1 and neurodegenerative disease: Inhibition of Drp1 ameliorates mitochondrial and synaptic dysfunction in 7 month-old APP/PS1 and 3 month-old CRND8 APP transgenic AD mice (Baek et al., 2017; Wang et al., 2017), as well as in other neurodegenerative diseases (Filichia et al., 2016).