APP and Alzheimer disease: This microglial activation was further confirmed by western blotting (mPFC, WT: 1 ± 0.19; APP/PS1: 3.00 ± 0.30; p = 0.0014; Figures 6F,G) (HIPP, WT: 1 ± 0.09; APP/PS1: 1.59 ± 0.09; p = 0.005; Figures 7F,G), suggesting a remarkable enhancement of microglial activation, and likely subsequent neuroinflammation, at this age in AD mice.