GFAP and Anxiety: In addition, comparison of GFAP-IR in the male Wistar-Kyoto (WKY) rat, which is commonly used as a model in studies of anxiety-like and depressive-like behaviors due to heightened stress-sensitivity, to male Sprague-Dawley rats, found that overall GFAP expression was lower in the PFC, basolateral amygdala (BLA), and hippocampus of the WKY rats (Gosselin et al., 2009).