NR3C1 and Anxiety: These include blunted hypothalamic-pituitary-adrenal (HPA) axis reactivity, reduction in glucocorticoid receptor (GR) expression in key emotional substrates, and increased anxiety (Liu et al., 1997; Caldji et al., 1998, 2000; Francis and Meaney, 1999; Francis et al., 1999; Weaver et al., 2004; Turecki and Meaney, 2016).