Dgcr8 haploinsufficiency in 22q11DS leads to depletion of thousands of miRNAs and the resultant upregulation of multiple targets, which in turn, disrupts or otherwise alters synaptic transmission, synaptic plasticity, and proper functioning of multiple neural circuits responsible for different behaviors (Earls and Zakharenko, 2013). This evidence concerns the gene DGCR8 and 22q11.2 deletion syndrome.