In another instance, Dgcr8 haploinsufficiency in 22q11DS mice led to the depletion of miR-25 and miR-185, the upregulation of Serca2 protein (encoded by Atp2a2), and an age-dependent increase in synaptic plasticity (Earls et al., 2010, 2012; Figure 2D). This evidence concerns the gene DGCR8 and 22q11.2 deletion syndrome.