In this regard, a study showed that dyclonine, an oral anesthetic that confers topical anesthesia to mucous membranes, induced frataxin expression in FRDA lymphoblasts and cerebellum of YG8R and KIKO mice, as well as in buccal cells of FRDA patients (Sahdeo et al., 2014). This evidence concerns the gene FXN and Friedreich ataxia.