NFE2L2 and Friedreich ataxia: Nuclear factor erythroid-2-related factor 2 signaling pathway has been shown to be disrupted in patients’ cells and different FRDA models, rendering the cells more susceptible to oxidative damage due to decreased antioxidant dxsefenses (Wong et al., 1999; Chantrel-Groussard et al., 2001; Sturm et al., 2005; Al-Mahdawi et al., 2006).