The correlation of P. gingivalis infection and low Beclin1 expression with the clinicopathological parameters in ESCC patients was analysed by the chi-squared test and the results showed that it was related to sex, age, smoking and alcohol consumption, which suggests that the oral microenvironment of older male ESCC patients with smoking and alcohol intake was worse, Patients with these features were more susceptible to persistent P. gingivalis colonization and exhibited low Beclin1 expression. The gene discussed is BECN1; the disease is esophageal squamous cell carcinoma.