With a solid validation in our well‐characterized cohorts comprised of 295 UBUC patients and 340 UTUC patients as mentioned earlier,22 the present study disclosed MYC amplification, high MYC expression, high HK2 expression and low hsa‐miR‐429 expression were correlated with high pathological tumour (pT) stage, nodal metastasis, high histological grade, vascular and perineural invasion, a high mitotic rate and amplification/high expression of CEBPD. This evidence concerns the gene HK2 and neoplasm.