The specific gene sets and functional sets enrichment analysis indicated that lncRNAs in CRC tumorigenesis predominantly regulated tumorigenesis-related biological processes, such as the P53 signaling pathway, KRAS signaling pathway, MET activates the PTK2 signaling pathway, cell cycle, cell growth, and cell metabolism as well as the process of EMT, while lncRNA CRC metastasis predominantly regulated immunity-related biological processes as well as blood vessel morphogenesis, which contributes to cancer metastasis (Figure 7B–7D). The gene discussed is TP53; the disease is cancer.