Considering the higher fold change of differential expression in PT compared to NM and higher degree in the lncRNA-mRNA co-expression network in PT, 10 candidate lncRNAs were further selected and considered as the most key CRC tumorigenesis-associated lncRNAs, including (NONHSAT080207 (ZFAS1--TCGA), NONHSAT088948 (LINC01811), NONHSAT122659 (LINC02577), NONHSAT055374 (LINC02563), NONHSAT123833 (LINC-PRSS2-6), NONHSAT072238 (LINC-EIF2AK3-4), NONHSAT141627 (LINC-ZG16-1), NONHSAT126299 (LINC-DKK4-1), NONHSAT133328, NONHSAT037943 (LINC-CIPC-4)]. The gene discussed is ZFAS1; the disease is colorectal carcinoma.