TP53 and colorectal carcinoma: The KEGG pathway analysis revealed that upregulated mRNAs in CRC metastasis were primarily involved in the p53 signaling pathway, ECM-receptor interaction, and pathways in cancer (Figure 6C), while downregulated mRNAs in CRC metastasis were primarily involved in pancreatic secretion pathways, which were similar to those in tumorigenesis, hematopoietic cell lineage, mineral absorption, drug metabolism, and B cell receptor signaling pathway (Figure 6D).