Protein-protein interaction enrichment analysis and molecular complex detection (MCODE) analysis revealed that five proteins (RFC3, TOP2A, CHEK1, DDX3Y, NOP2) related to P53-signal transduction were identified as the densely connected network components regulated by key lncRNAs in CRC tumorigenesis (Figure 3E). The gene discussed is TOP2A; the disease is colorectal carcinoma.