Overall, these results showed that lncRNAs in CRC tumorigenesis participated in the regulation of the EMT/P53/PI3K-Akt/KRAS signaling pathway as well as the process related to cell cycle and cell mitosis, which may provide novel clues for the biological effects of lncRNAs on CRC tumorigenesis. The gene discussed is TP53; the disease is colorectal carcinoma.