P2RY8 and central nervous system cancer: We observed that the IRSs of PROS1, P2RY8, PLAU, CHI3L2, MSR1, CCR5, and TRIM38 were higher than its corresponding IRSs in low-grade glioma, while the IRSs of HAMP, CARD16, and S100A8 in high-grade glioma were lower than low-grade glioma (Figure 9D).