Although DSS-treated mice (both saline- and vehicle-injected groups) exhibited a significant increase in visceromotor response (VMR) to colorectal distension (CRD), pharmacological inhibition of spinal P2RY12 by MRS2395 completely blocked colitis-induced VHS compared with the vehicle-injected group (Figure 11B). This evidence concerns the gene P2RY12 and colitis.