TRPV1 and colitis: Chronic CNO treatment did not affect colitis-induced body weight loss, macroscopic damages, cytokine production in TRPV1-hM4Di (Figure 6A to 6F), or hM4Di littermate controls (Figure 5D to 5H; Table 1), indicating that inhibition of TRPV1 visceral afferents was not sufficient to reduce the severity of colitis.