(2), Bauman et al. (3), and Park and Scott (4) demonstrated the enhanced expression of CH25H in immune cells in response to bacterial infection, whereas two articles published in 2013 further established Ch25h as an IFN-stimulated gene and its product 25-HC to be antiviral against a broad range of enveloped viruses (8, 9). This evidence concerns the gene CH25H and bacterial infectious disease.