In 2011, soon after the seminal articles of Baumann et al. (3), Diczfalusy et al. (2), and Park and Scott (4) linking TLR, IFN, CH25H, and 25-HC to the immune response against bacterial infection (2, 3, 4), Blanc et al. (10) proposed a mechanism by which the host defends itself against viral infection through IFN-mediated downregulation of sterol biosynthesis. This evidence concerns the gene IFNA1 and bacterial infectious disease.