DHRS9 gene is frequently cited as a differentially expressed gene in such diseases as colorectal cancer (29), cicatricial alopecia (30), polycystic ovary syndrome (31), oral squamous cell carcinoma (32), rheumatoid arthritis (50), pancreatic cancer (51), etc. Consequently, examination of the physiological role of DHRS9 in the metabolism of oxylipins initiated with this study should shed light on the contribution of DHRS9 to pathophysiology of cancer progression and potentially other diseases linked to inflammation. This evidence concerns the gene DHRS9 and oral cavity squamous cell carcinoma.