In addition, altered secretion of CTGF and TGF-β derive from nicotine-exposed-fibroblasts also significantly enhances the migration and EMT of breast cancer and Nicotine may modulate the expressions of CTGF and TGF-β by activating α7 nAChR-dependent AKT/TAZ signaling [11]. This evidence concerns the gene TGFB1 and breast cancer.