For example, the molecular mechanism underlying the anxiolytic and antidepressant-like effect of GLO1 inhibitors is thought to be due to GABAA receptor stimulation by accumulated MG [39], but there is still no direct evidence that decreased GLO1 activity actually stimulates the GABAergic system in the brain, including the hippocampus and prefrontal cortex, through MG accumulation, leading to low levels of anxiety. Here, GLO1 is linked to Anxiety.