PGLS and breast cancer: Recently, studies showed that PGLS was aberrantly highly expressed in various cancers, including cervical cancer, breast cancer, glioblastomas, and hepatic cancer, etc.21, 22, 23, 24, 25Batsios et al found that PGLS was up‐regulated in glioblastoma and knockdown of PGLS could significantly reduce NADPH and GSH.