Further, in our daily work, a previously SMAD6‐positive RUS family (M2553; Yang et al., 2019) consulted with our laboratory for counseling about the risk of recurrence and the possible explanations, because their new‐born baby (II:3) is suffering from CHD but without RUS and carries the same SMAD6 variant as the family RUS proband (Figure 4). The gene discussed is SMAD6; the disease is coronary artery disorder.