Among the 30 patients in the sequential chemotherapy group, 13 patients (12 patients in the efficacy analysis population) were able to receive both prior FOLFIRI and subsequent FOLFOX chemotherapy, and among them, progressive disease (PD) of prior FOLFIRI was determined by imaging in 7 patients and by elevated tumor markers, such as CEA and CA19‐9, in 6 patients. This evidence concerns the gene CEACAM5 and neoplasm.