ZFHX3 and posterior cortical atrophy: Notably, the transcriptional regulation of ZFHX3 by the androgen/AR signalling also occurs in vivo, as castration‐mediated androgen depletion in mice downregulated ZFHX3 mRNA and protein levels in the prostate and the ZFHX3 mRNA levels positively correlated with AR activities in human PCa specimens (Figure 4).