Meanwhile, ZFHX3 has also been shown to modulate both normal development and carcinogenesis of the prostate, as ZFHX3 is frequently mutated in advanced human prostate cancer and loss of Zfhx3 in mouse prostates causes or promotes prostatic carcinogenesis.11, 13, 14, 15. Here, ZFHX3 is linked to Familial prostate cancer.