We examined the effects of molecules on protein aggregation and neurite swelling in the SLO‐treated ALS MN cultures, including the current ALS medication Edaravone, autophagy activators STF‐62247, SMER28, Flubendazole, and the peptide Tat‐Beclin, and KU‐60019, a molecule identified from our initial cell toxicity screening as neuroprotective. This evidence concerns the gene TAT and amyotrophic lateral sclerosis.