ZMPSTE24 and lipodystrophy: Lopinavir also inhibits ZMPSTE24 (Coffinier et al., 2007; Mehmood et al., 2016), thereby blocking lamin A biogenesis and leading to an accumulation of prelamin A. ZMPSTE24 deficiency in humans causes an accumulation of prelamin A and leads to lipodystrophy and premature aging (Afonso et al., 2016; Spear et al., 2018; Wang et al., 2016), which perhaps causes senescence phenotype in our cultured neurons.