As a crucial molecule of the Wnt signaling pathway, sFrp2 regulates the proliferation, apoptosis, and differentiation of stem cells by inhibiting the Wnt signaling pathway to be involved in multiple biological processes such as cardiac malformations and cardiovascular diseases,45 the regulation of skin and hair follicle development,46 and the occurrence, development, and prognosis of gastric cancer.47 Here, SFRP2 is linked to gastric cancer.