Gao et al. screened the plasma of patients with persistent atrial fibrillation by circRNA microarray and found that hsa_circ_0004104 was significantly downregulated; hsa_circ_0004104 negatively correlated with TGF‐β1, suggesting the potential of hsa_circ_0004104 as a biomarker for persistent AF.32 This evidence concerns the gene TGFB1 and atrial fibrillation.