However, with the development of research in recent years, it has been reported that the NT Pro‐BNP is also produced in the atrial wall,17 the main stimulus for cardiac NT Pro‐BNP secretion is myocardial stretch;16 AF is usually associated with changes in atrial muscle tone and may also lead to changes in NT Pro‐BNP secretion. This evidence concerns the gene NPPB and atrial fibrillation.