LCN2 and infection: However, the pathways of extracellular matrix disassembly, negative regulation of kinase activity, cellular response to reactive oxygen species, cellular response to oxidative stress, cellular response to chemical stress, neutrophil mediated immunity, granulocyte activation and leukocyte cell-cell adhesion had become the central points at 120 h post infection, and many molecules, such as CST3, A2M, RAB6A, LCN2, TGFB1, CASP3, CXCL12 were connecting points among these important pathways, connecting multiple signaling pathways to each other and forming a complex and integrated network.