The RBD antigen has never been shown to induce ADE of SARS-CoV-2 infection.36,37 A recent in vitro study showed that the infectivity-enhancing antibodies recognized a specific site on the N-terminal domain (NTD) of SARS-CoV-2 S protein.38 However, another study suggested that these infection-enhancing antibodies targeted NTD could facilitate virus infection in vitro, but increased lung inflammation can hardly occur in antibody-infused macaques.39 The gene discussed is PROS1; the disease is infection.