In the current study, we observed robust increases of proinflammatory cytokines/chemokines in sera and BALF, such as TNF-α, IL-1β, IL-6, KC, MCP-1, RANTES, and MIP-1α/β27,28 which correlate with those observed in severe COVID-19 and ARDS patients. Here, CALCA is linked to acute respiratory distress syndrome.