Recently, Alexanian et al. utilized single-cell sequencing technology to uncover stress-activated signaling cascades involved in fibroblast activation in a murine model of heart failure.1 Since the preclinical studies of cardiac disease models showed strong reduction in fibrosis after BET inhibition, they used the BET inhibitor JQ1 for a temporally controlled perturbation of transcription signaling. This evidence concerns the gene DNER and heart disorder.