EIF5A and diabetes mellitus: Despite these data, and using a “humanized” transgenic mouse model for type 1 diabetes, Imam et al. [128] failed to demonstrate a protective effect of inhibition of DHPS on the development of type 1 diabetes, even if down-regulation of eIF5A changed the pathophysiology, and observed immune outcome of diabetes in an animal model that is very similar to that of human type 1 diabetes (Fig. 4).