TNF and amyloidosis: In the course of inflammatory response, the continuous production of pro-inflammatory factors such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) [11, 12] can cause various nervous system lesions, including amyloidosis, neuronal death [13, 14], cortical thinning [15, 16], reduced brain volume [15], cerebral vascular disease related events such as micro hemorrhage, infarcts [17, 18] and neurodegeneration [2].