TP53 and esophageal squamous cell carcinoma: Notably, K120 and K164 acetylation sites are located in the p53 DNA-binding domain, which is the most commonly mutated region of p53 in solid tumors, A K120 mutation was identified in Ewing's Sarcoma and esophageal SCC cells, whereas a K164 mutation was discovered in glioblastoma and bladder cancer cells [70] suggesting that acetylation of these particular residues is critical for p53 function.