TP53 and cancer: The wild-type TP53 gene is translated into p53 proteins, which are transcription factors with an important role in orchestrating a variety of cellular responses such as DNA repair, cell cycle arrest, cellular senescence, cell death, cell differentiation, and metabolism thereby driving inhibitory molecular processes on cancer growth (Fig. 1) preserving genomic integrity, thus acting as "guardian of the genome" [10, 11].