TP53 and neoplasm: The p53/p21/p27 and p53/Bcl-2/Bax pathways affect many biological processes including cell proliferation, G2/M phase and apoptosis [15] as in fact 53 tumor suppressive function might work through the recruitment or regulation of other tumor suppressor proteins such as the Inter-Alpha-Trypsin Inhibitor Heavy Chain 5 proyein, encoded by the ITIH5 gene.