TARDBP and proteostasis deficiencies: Similar to previous reports, (Kersaitis et al., 2004, Schofield, 2003, Cooper et al., 1996) we also observed high levels of GFAP-positive gliosis in PiD across all cortical layers but, in contrast to FTLD-TDP, these cellular structures were largely not visualized by iron staining, suggesting a potential unique process of astrocyte-mediated iron dysregulation in TDP-43 proteinopathies.