While the gross anatomical location of a high burden of pathology in primary motor cortex in these tauopathies31, (Ahmed et al., 2013) partially overlaps with regional patterns of pathology in ALS, (Kwan et al., 2012, Brettschneider et al., 2013) the MRI and pathological features of these FTLD-Tau cases are distinct in the addition of prominent iron-rich gliosis in adjacent WM. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.