Previous histopathological studies suggest relative bilaminar distribution of tau inclusions, (Armstrong et al., 1999, Armstrong and Cairns, 2012, Irwin et al., 2016) and gliosis (Kersaitis et al., 2004, Schofield, 2003, Hasegawa et al., 2018, Cooper et al., 1996) with greater WM degeneration60, (Giannini et al., 2021) in FTLD-Tau. Here, MAPT is linked to Gliosis.