We previously described that SIRT1 expression was increased in the livers from primary sclerosing cholangitis and primary biliary cholangitis patients as well as in mice following bile duct ligation (BDL) and that the overexpression of SIRT1 contributed to cholestatic disease progression in SIRToe mice after BDL.27 The gene discussed is SIRT1; the disease is biliary liver cirrhosis.