Higher levels of pro-inflammatory adipocytokines such as leptin, visfatin, resistin, IL-6, IL-8, IL-31, IL-33, TNF-α, GDF, Oncostatin M and SDF-1 are associated with an advanced state of endometrial cancer such as high grade II/III, deeper myometrial invasion, lymph vessel invasion, lymph node metastasis, shorter survival and recurrence [40, 58, 59, 66, 68, 70–80]. The gene discussed is RETN; the disease is endometrial cancer.