Che et al. [47] reported that addition IL-6 antibody to a co-culture of estradiol and endometrial cancer cells abrogated the estradiol-induced increased endometrial cancer cell apoptosis inhibition markers Bcl-2 and Mcl-1, which lead to the conclusion that IL-6 is necessary for the estradiol-induced inhibition of endometrial cancer cell apoptosis. The gene discussed is MCL1; the disease is endometrial cancer.