KRT8 and colonic disorder: Since the colonic hyperproliferation [11], cell fate switch [17] and tumorigenesis susceptibility[18] described in the full K8–/– closely resembling that of the intestinal epithelial-specific K8 mice described here (comparisons on colon disease and molecular phenotypes are listed in Supplemental Tables 1 and 2), the current study strongly underlines the importance of colonic epithelial keratins for colon health and homeostasis.