While global Angptl4 deficiency results in increased visceral adipose tissue mass and inflammation in mice under high-fat diet (HFD) [27], adipose tissue specific Angptl4 depletion has beneficial effects on lipid metabolism, ectopic fat accumulation in liver and muscle and, glucose intolerance in HFD-fed animals [28]. The gene discussed is ANGPTL4; the disease is Glucose intolerance.