IFNγ-induced decrease in Fasn and Fads2 expression correlated with reduced Abca1 and Dhcr24 transcript levels after 6 hr of infection (Figure 2D), suggesting that IFNγ prevents Mtb-induced stimulation of FA biosynthesis through downregulation of LXR and SREBP1 activity. The gene discussed is ABCA1; the disease is infection.