KRAS and Patent ductus arteriosus: To survive and proliferate in this nutrient austere tumor microenvironment (TME), the oncogenic driver in PDA, mutant Kras, facilitates the rewiring of PDA metabolism (Halbrook and Lyssiotis, 2017; Perera and Bardeesy, 2015; Ying et al., 2016; Kerk et al., 2021).