On the other hand, focal cerebral ischemia model mice, as established by F Shen et al., displayed upregulated HIF-1α expression in the ischemic area and elevated VEGF expression in the ischemic perifocal region, with increased total numbers of microvessels and newly formed microvessels, which promote the recovery of injured nerves after ischemia [35]. The gene discussed is HIF1A; the disease is ischemia.