In a similar vein, Mi Yang et al. demonstrated that miR-497-195 maintains HIF-1α stability to increase angiogenesis and reduce bone loss by targeting FBXW7 [45], indicating that FBXW7 protects the brain of neonatal HIBD rats by promoting angiogenesis and reducing the cerebral infarction area. Here, FBXW7 is linked to cerebral infarction.